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Summary and pathological significance of HA size in vivo. HA molecular weight (MW) is divided into very high (vHMW 6000-12000 kDa; naked mole rat HA), high (HMW > 1000 kDa), medium (MMW 250-1000 kDa), low (10-250 kDa), and Oligo-HA (< 10 kDa). Green text highlights positive roles for each HA MW in tissue function and recovery, whereas red text favors pathological decline. Opposing and/or unclear tissue responses are designated in orange-colored text.
