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. 2015 May 9;15:380. doi: 10.1186/s12885-015-1369-8

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© Shi et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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KPNA2 knockdown induces apoptosis in urothelial carcinoma cells. (A,B) The apoptosis rate, as evaluated by flow cytometry analysis using Annexin-V/PI staining. (C,D) The percentage of cells with mitochondrial Δψm disruption, as evaluated by flow cytometry analysis using the JC-1 dye. (E) Caspase 3/7 activity of T24 and J82 cells transfected with control or KPNA2-directed siRNA. The data in (A–E) represent the mean ± SD of three independent tests performed in triplicate. *P < 0.05. (F) Western blot analysis of PARP cleavage and PCNA expression in control and KPNA2 knockdown cells.