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. Author manuscript; available in PMC: 2015 May 15.
Published in final edited form as: J Nucl Med. 2010 Jan;51(1):121–129. doi: 10.2967/jnumed.109.066126

FIGURE 4.

FIGURE 4

Blocking of 124I-SKI230 in vivo uptake within engrafted tumor. (A) Transaxial images of representative rat (n = 3) before PKI treatment. (B) Transaxial images of same rat after cold SKI230 administration, demonstrating in vivo displacement of radiotracer by micromolar concentration of systemically administered PKI. (C) 124I-SKI230 tumor uptake after blocking with cold SKI230 (open bars) is reduced, compared with pretreatment uptake (solid bars). (D) Imaging of negative-control A-431 tumor model.