Table 4.
Biodistribution (%ID/organa and %ID/ga) of [99mTc(CO)3S2P-BBN]+ (11) in Normal CF-1 Mice at 1 h, 4 h, and 24 h, Post-IV-Injection
| organ | time
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 h
|
4 h
|
24 h
|
||||||||||
| % ID | %ID/g | % ID | %ID/g | % ID | %ID/g | |||||||
| tail | ||||||||||||
| brain | 0 | (0.00) | 0 | (0.00) | 0 | (0.00) | 0 | (0.00) | 0 | (0.00) | 0 | (0.00) |
| bloodb | 1 | (2) | 0.67 | (0.84) | 0.43 | (0.12) | 0.15 | (0.04) | 0 | (0.00) | 0 | (0.00) |
| heart | 0.02 | (0.01) | 0.14 | (0.03) | 0.01 | (0.01) | 0.04 | (0.02) | 0.06 | (0.11) | 0.4 | (0.6) |
| lung | 0.08 | (0.06) | 0.33 | (0.25) | 0.03 | (0.01) | 0.15 | (0.04) | 0.02 | (0.01) | 0.07 | (0.05) |
| liver | 6.5 | (0.8) | 3.4 | (0.36) | 3.3 | (0.74) | 1.6 | (0.4) | 0.9 | (0.1) | 0.4 | (0.06) |
| spleen | 0.09 | (0.02) | 0.66 | (0.17) | 0.03 | (0.01) | 0.15 | (0.07) | 0.02 | (0.02) | 0.12 | (0.17) |
| stomach | 0.52 | (0.22) | 0.93 | (0.42) | 0.8 | (0.7) | 1.1 | (0.8) | ||||
| l. int | 16.4 | (14) | 19.0 | (21) | 30 | (19) | 33 | (22) | 4 | (2) | 3 | (2) |
| sm. int | 42.0 | (14) | 26.3 | (7) | 9.3 | (6) | 5.6 | (4.1) | 1.1 | (0.7) | 0.6 | (0.4) |
| kidney | 0.49 | (0.03) | 1.0 | (0.1) | 0.22 | (0.04) | 0.44 | (0.05) | 0.07 | (0.01) | 0.13 | (0.02) |
| urine | 20.3 | (6) | 45.7 | (14) | 38 | (3) | ||||||
| muscle | 0.03 | (0.01) | 0.15 | (0.04) | 0.04 | (0.07) | 0.2 | (0.4) | 0.01 | (0.02) | 0.02 | (0.05) |
| bone | 0.01 | (0.01) | 0.1 | (0.06) | 0.04 | (0.07) | 0.5 | (1) | 0 | (0.01) | 0.04 | (0.08) |
| pancreas | 3.0 | (1) | 8.7 | (2) | 0.47 | (0.10) | 1.1 | (0.15) | 0.11 | (0.02) | 0.27 | (0.06) |
| carcass | 10.2 | (2) | 3.7 | (1) | 1.5 | (0.9) | ||||||
| feces | 52.8 | (6.6) | ||||||||||
a
Values represent the mean (±SD), N = 5 of the %ID/organ or the %ID/g of tissue. Body weights of mice ranged from 21 to 28 g.
b
Total blood volume is estimated to be 6.5% of the total body weight.