All-atom model of mature HIV-1 capsid. a, b. Representative slices of the three-dimensional cryo-ET data. Red arrows indicate arrays of CA hexamers, and yellow stars indicate locations of sharp curvature change. The scale bar is 20 nm. c. A overlay of the fullerene model (green) and the densities from the segmented capsid (orange). d. All-atom molecular dynamics equilibrated model of mature HIV-1 capsid comprising 216 CA hexamers (blue, NTD; orange, CTD) and 12 CA pentamers (green). Reprinted with permission from Zhao et al., Nature, 2013, 497, 643–646. Copyright 2013 Nature Publishing Group.