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. 2015 May 3;57(1):21. doi: 10.1186/s13028-015-0112-4

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© Casoni et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Parent-metabolite pharmacokinetic model for S-ketamine and S-norketamine. V₁: Volume of the central compartment; Cl₁: Clearance from the central compartment; V₂: Volume of the peripheral compartment; Cl₂: Clearance from the peripheral compartment; Cl_ParMet: Clearance from S-ketamine to S-norketamine.