Table 4.
Final population pharmacokinetic parameters
| Pk paramaters | S-ketamine | S-norketamine |
|---|---|---|
| V1 (mL/kg) | 132.7 | 59.9 |
| Cl1 (mL/kg/min) | 36.3 | 30 |
| V2 (mL/kg) | 376.3 | |
| Cl2 (mL/kg/min) | 14.9 | |
| ClParMet (mL/kg/min) | 21.1 | |
| t1/2 (min) | 8.5 | 8.6 |
| Cltot (mL/kg/min) | 44.5 | |
| Vss (mL/kg) | 191.4 | |
| AUC (μg/min/mL) | 56.2 | 16.2 |
| AUMC (μg/min2/mL) | 241.6 | 272.5 |
| MRT (min) | 4.3 | 16.82 |
| Cmax (μg/mL) | 0.8 | |
| Tmax (min) | 7.4 |
V1: Volume of the central compartment; Cl1: Clearance from the central compartment; V2: Volume of the peripheral compartment; Cl2: Clearance from the peripheral compartment; ClParMet: Clearance from S-ketamine to S-norketamine; t1/2: Elimination half-life; Cltot: Total body clearance; Vss: Volume of distribution at steady-state; AUC: Area under the time course curve; AUMC: Area under the moment of the time course curve; MRT: Mean residence time; Cmax: Maximum concentration; Tmax: Time at maximum concentration.