Table 5.
COMT 158A>G Dominant Modela
| Neonatal Abstinence Syndrome Outcome | COMT AA (n = 16) | COMT AG/GG (n = 68) | P Value for Unadjusted | Adjusted Difference (95% CI) | P Value for Adjusted |
|---|---|---|---|---|---|
| LOS, mean (95% CI), d | 31.1 (23.5 to 38.7) | 20.4 (16.5 to 24.3) | .014b | β = −10.8 (−18.2 to −3.4)c | .005 |
| Infants treated, No. (%) | 14 (87.5) | 41 (60.3) | .04d | OR, 0.79 (0.69 to 0.99) | .02 |
| ≥2 Medications, No. (%) | 9 (56.2) | 12 (17.6) | .001d | OR, 0.68 (0.55 to 0.86) | .001 |
| Maximum daily morphine, mean (95% CI), mg | 2.10 (1.63 to 2.57) | 1.74 (1.59 to 1.89) | .05b | ||
| Maximum daily methadone, mean (95% CI), mg | 1.78 (1.36 to 2.20) | 1.58 (1.42 to 1.74) | .59b | ||
| Maximum score, mean (95% CI)e | 13.6 (11.6 to 15.6) | 11.3 (10.6 to 12.0) | .03b | β = −2.3 (−4.0 to −0.5) | .011 |
Abbreviations: COMT, catechol-O-methyltransferase; LOS, length of stay; OR, odds ratio.
a
Adjusted analyses performed only for our primary outcome measure of LOS and those with P <.05. All analyses were adjusted for breastfeeding and study site.
b
P values for unadjusted results were calculated with 2-sample t tests.
c
β Coefficients indicating between-group differences in LOS were calculated with linear regression models.
d
P values for unadjusted results were calculated with a χ2 test of independence.
e
Maximum modified Finnegan score during the hospitalization.