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. Author manuscript; available in PMC: 2016 Mar 11.
Published in final edited form as: J Am Chem Soc. 2015 Mar 3;137(9):3338–3351. doi: 10.1021/ja512690x

Table 10.

Hetero-Diarylation of Alanine Substratea,b

graphic file with name nihms688285f17.jpg
a

Conditions: Substrate 1 (0.1 mmol), Pd(OAc)2 (10 mol%), AgOAc (0.2 mmol), Ar1–I (0.12 mmol), 2-picoline (20 mol%), HFIP (1.0 mL), 75 °C, 24 h. Then Pd(OAc)2 (10 mol%), AgOAc (0.2 mmol), Ar2–I (0.3 mmol), 2,6-lutidine (20 mol%), NaH2PO4•H2O (0.3 mmol), 100 °C, 36 h.

b

Isolated yields are shown.