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. Author manuscript; available in PMC: 2016 Mar 11.
Published in final edited form as: J Am Chem Soc. 2015 Mar 3;137(9):3338–3351. doi: 10.1021/ja512690x

Table 11.

Arylation of Other Amino Acids and Carboxylic Acidsa

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a

Isolated yields are shown.

b

Conditions: Substrate (0.2 mmol), Pd(OAc)2 (10 mol%), AgOAc (0.4 mmol), p-Tol–I (0.3 mmol), 2-picoline (20 mol%), HFIP (2.0 mL), 80 °C, 24 h.

c

Conditions: Substrate (0.1 mmol), Pd(OAc)2 (10 mol%), AgOAc (0.2 mmol), p-Tol–I (0.3 mmol), 2,6-lutidine (20 mol%), NaH2PO4•H2O (0.3 mmol), HFIP (1.0 mL), 90 °C, 36 h.

d

Substrate (0.1 mmol), Pd(OAc)2 (15 mol%), AgOAc (0.2 mmol), p-Tol–I (0.3 mmol), L1 (30 mol %), TFA (20 mol %), DCE (1.0 mL), 85 °C, 36 h.