Table 6.

Additive Screening in the Arylation of Phenylalanine^a,^b

Entry	Additives (equiv)	% Yield
1	no	10
2	K2CO3	0
3	KHCO3	8
4	K3PO4(0.5)	14
5	K2HPO4	40
6	KH2PO4	30
7	KF	16
8	Na2HPO4	32
9	NaH2PO4•H2O	50
10	NaH2PO4	49
11	LiH2PO4	36
12	LiOAc	0
13	NaH2PO4•H2O(1.5)	56
14	NaH2PO4•H2O (2)	66
15	NaH2PO4•H2O (3)	72
16	NaH2PO4•H2O (4)	70

^aConditions: Substrate 2′ (0.1 mmol), Pd(OAc)₂ (10 mol%), AgOAc (0.2 mmol), p-Tol–I (0.3 mmol), L1 (20 mol%), HFIP (1.0 mL), 100 °C, 36 h.

^bDetermined by ¹H NMR analysis of the crude product using CH₂Br₂ as an internal standard.