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. Author manuscript; available in PMC: 2016 Jan 7.
Published in final edited form as: Anal Chim Acta. 2014 Nov 11;854:95–105. doi: 10.1016/j.aca.2014.11.009

Table 1.

Definitions of the statistical characteristics used for network analysis in this study.

Statistical characteristic Symbol Equationa,b,c,d Description
Degree k
ki=j=1Neij
The total number of edges for a node i
Average degree <k>
<k>=i=1NkiN
The average degree of the network
Average path length L
L=1N(N1)ijdij
The mean distance between two nodes, averaged over all pairs of nodes
Diameter D D = max{dij} The maximum distance between any pair of nodes
Clustering coefficient C
Ci=2eiki(ki1)(ki2)
The probability that two nodes are linked to each other given that they are both connected to node i
Degree centrality Cd
Cd=kiN1
The proportion of other nodes that are adjacent to node i
Betweenness centrality Cb
Cb=j(<k)NkNgjk(i)gjk
The proportion of all geodesics between pairs of other nodes that include this node i
Closeness centrality Cc
Cc=N1j=1Ndij
The number of other nodes divided by the sum of the distances between the node i and all the other nodes
a

eij is the numbers of edges from node i to j.

b

dij is the shortest path length from node i to j.

c

N is the total number of nodes in the network.

d

gjk is the numbers of geodesics connecting nodes j and k.