Table 3.

Altered plasma metabolites between young hypertensive men and healthy controls.

Group	Compound	Fold changeb,c	Regulationd	Adjusted P-valuee	Retention time (min)	Retention indexf
Organic acids	Oxalic acid	4.47	Up	1.05E-05	6.8	1119.6
	Fumaric acid	2.8	Up	6.20E-05	14.18	1339.2
	L-valinea	−1.17	Down	4.17E-02	10.63	1204.6
	L-isoleucinea	−1.22	Down	1.99E-02	12.59	1281.3
	Glycinea	−2.98	Down	4.78E-06	12.99	1296.7
	L-threoninea	−1.23	Down	1.98E-03	15.05	1370.5
	L-methioninea	−1.47	Down	1.76E-02	18.97	1506.8
	Ornithinea	−3.42	Down	1.64E-03	21.63	1601.8
Amino acids	L-asparaginea	−1.42	Down	1.89E-03	23.14	1656.9
	L-glutaminea	−1.67	Down	3.90E-03	25.98	1762.2
	Citrullinea	−1.85	Down	1.70E-04	27.33	1804.2
	L-lysinea	−1.9	Down	1.22E-05	29.81	1908.1
	L-tyrosinea	−2.8	Down	3.90E-03	30.24	1924.9
	L-tryptophana	−1.42	Down	3.98E-04	36.72	2200.1
	L-cystinea	−1.95	Down	5.30E-05	38.42	2277
Carbohydrates	Glycerol	1.26	Up	4.32E-02	11.98	1257.4
Lipids	Capric acid	−1.58	Down	6.51E-03	17.49	1448.2
	Adenine	3.4	Up	4.47E-06	20.35	1555.9
Others	Pyrophosphate	2.38	Up	1.69E-02	22.81	1645.5
	Uric acid	1.28	Up	1.37E-02	34.06	2083.2

^aMetabolites confirmed by measuring reference substances.

^bFold change was calculated as a relatively ratio of the relative peak intensities between different groups.

^cPositive value, patients vs. controls; negative value, controls vs. patients.

^d“Up” or “Down” means the trend of regulation for these metabolites in young hypertensive patients versus controls.

^eP-values were adjusted using Benjamini and Hochberg procedure (BH method) with an FDR of less than 5%.

^fRetention index was calculated relative to n-alkane standards.