Table 3.
Group | Compound | Fold changeb,c | Regulationd | Adjusted P-valuee | Retention time (min) | Retention indexf |
---|---|---|---|---|---|---|
Organic acids | Oxalic acid | 4.47 | Up | 1.05E-05 | 6.8 | 1119.6 |
Fumaric acid | 2.8 | Up | 6.20E-05 | 14.18 | 1339.2 | |
L-valinea | −1.17 | Down | 4.17E-02 | 10.63 | 1204.6 | |
L-isoleucinea | −1.22 | Down | 1.99E-02 | 12.59 | 1281.3 | |
Glycinea | −2.98 | Down | 4.78E-06 | 12.99 | 1296.7 | |
L-threoninea | −1.23 | Down | 1.98E-03 | 15.05 | 1370.5 | |
L-methioninea | −1.47 | Down | 1.76E-02 | 18.97 | 1506.8 | |
Ornithinea | −3.42 | Down | 1.64E-03 | 21.63 | 1601.8 | |
Amino acids | L-asparaginea | −1.42 | Down | 1.89E-03 | 23.14 | 1656.9 |
L-glutaminea | −1.67 | Down | 3.90E-03 | 25.98 | 1762.2 | |
Citrullinea | −1.85 | Down | 1.70E-04 | 27.33 | 1804.2 | |
L-lysinea | −1.9 | Down | 1.22E-05 | 29.81 | 1908.1 | |
L-tyrosinea | −2.8 | Down | 3.90E-03 | 30.24 | 1924.9 | |
L-tryptophana | −1.42 | Down | 3.98E-04 | 36.72 | 2200.1 | |
L-cystinea | −1.95 | Down | 5.30E-05 | 38.42 | 2277 | |
Carbohydrates | Glycerol | 1.26 | Up | 4.32E-02 | 11.98 | 1257.4 |
Lipids | Capric acid | −1.58 | Down | 6.51E-03 | 17.49 | 1448.2 |
Adenine | 3.4 | Up | 4.47E-06 | 20.35 | 1555.9 | |
Others | Pyrophosphate | 2.38 | Up | 1.69E-02 | 22.81 | 1645.5 |
Uric acid | 1.28 | Up | 1.37E-02 | 34.06 | 2083.2 |
Metabolites confirmed by measuring reference substances.
Fold change was calculated as a relatively ratio of the relative peak intensities between different groups.
Positive value, patients vs. controls; negative value, controls vs. patients.
“Up” or “Down” means the trend of regulation for these metabolites in young hypertensive patients versus controls.
P-values were adjusted using Benjamini and Hochberg procedure (BH method) with an FDR of less than 5%.
Retention index was calculated relative to n-alkane standards.