Table 1.
Characteristics of patients with probable Alzheimer’s disease according to new diagnostic guidelines a
| APOE ε4 carriers (n = 120) | APOE ε4 non-carriers (n = 63) | Group comparison P -values b | |
|---|---|---|---|
| Total number of patients | N = 183 | ||
| Age (yr) | 70.4 ± 6.4 | 70.4 ± 8.7 | 0.97 |
| Age at onset (yr) | 67.6 ± 7.2 | 66.8 ± 12.2 | 0.96 |
| Duration of disease (mo) | 31.3 ± 24.7 | 30.5 ± 25.4 | 0.84 |
| Males/females, n (ratio) | 57/63 (1:1.1) | 28/35 (1:1.3) | 0.70 |
| Education (yr) | 9.1 ± 1.8 | 9.4 ± 2.2 | 0.30 |
| Systolic blood pressure (mmHg) | 139.3 ± 17.0c | 141.1 ± 16.9d | 0.54 |
| Systolic blood pressure ≥140 mmHg (yes/no) | 57/42 (1.4 : 1) | 32/23 (1.4 : 1) | 0.95 |
| Diastolic blood pressure (mmHg) | 81.6 ± 8.7c | 83.8 ± 7.9d | 0.14 |
| Diastolic blood pressure ≥90 mmHg (yes/no) | 33/66 (1:2) | 20/35 (1:1.8) | 0.78 |
| Antihypertensive medication (yes/no) | 31/87 (1 : 2.8)e | 20/39 (1 : 2)f | 0.18 |
| Coronary heart disease (yes/no) | 7/111 (1 : 15.9)e | 5/56 (1 : 9.3)g | 0.57 |
| Diabetes (yes/no) | 16/102 (1 : 6.4)e | 6/53 (1 : 8.8)f | 0.45 |
| Hypercholesterolemia (yes/no) | 15/100 (1 : 6.7)h | 7/47 (1 : 6.7)i | 0.99 |
| BMI | 24.5 ± 3.9j | 24.2 ± 4.9i | 0.85 |
| CDR SOB | 4.3 ± 1.4 | 4.3 ± 1.6 | 0.92 |
| MMSE (score) | 23.8 ± 3.2k | 24.5 ± 2.9 | 0.51 |
| Delayed verbal recall (score) | 2.1 ± 2.0j | 2.8 ± 2.2 | 0.02 |
| Verbal learning | 12.1 ± 4.3j | 12.4 ± 4.4 | 0.87 |
| Trail Making Test A (s) | 96.6 ± 57.0l | 96.1 ± 52.3 | 0.60 |
| Constructive -apraxia | 9.0 ± 2.3k | 9.0 ± 1.8 | 0.59 |
| Boston Naming Test | 12.6 ± 2.4k | 12.8 ± 2.4 | 0.80 |
a APOE, Apolipoprotein E; BMI, Body mass index; CDR SOB, Clinical Dementia Rating Sum of Boxes; MMSE, Mini Mental State Examination. Data are presented as mean ± SD or ratio. b P-values are based on Student’s t-test. Available data: cn = 99, dn = 55, en = 118, fn = 59, gn = 61, hn = 115, in = 54, jn = 99, kn = 119, ln = 116.