Table 3.
Effects on total white matter hyperintensity volume (analysis of variance model with APOE ε4 status (non-carrier versus carrier as factor of interest) in subjects with white matter hyperintensity a ≤10 cm 3
| Model 1 (n = 183) | Model 2 (n = 129) | |||
|---|---|---|---|---|
| f (1, 169) | P -value | f (1, 107) | P -value | |
| APOE ε4 carrier status | 8.9 | 0.01 | 9.1 | 0.01 |
| Age | 39.7 | 0.01 | 42.6 | 0.01 |
| Sex | 1.5 | 0.22 | 2.4 | 0.13 |
| Education | 0.69 | 0.41 | 0.03 | 0.86 |
| Disease classification | 1.4 | 0.24 | 1.7 | 0.20 |
| Total intracranial volume | 4.9 | 0.03 | 9.2 | 0.01 |
| Duration of disease | 0.07 | 0.80 | ||
| MMSE scoreb | 0.004 | 0.95 | ||
| Systolic blood pressure | 0.16 | 0.69 | ||
| Diastolic blood pressure | 10.4 | 0.01 | ||
| Antihypertensive medication | 0.40 | 0.53 | ||
| Coronary heart disease | 0.004 | 0.95 | ||
| Cholesterol medication | 0.49 | 0.49 | ||
| Diabetes medication | 0.006 | 0.94 | ||
aResults for site covariates are not reported. bMMSE, Mini Mental State Examination.