Table 1.
Hemodynamic and respiratory variables in sham versus LPS animals
| Variable | Group | A | B | C | D | P a |
|---|---|---|---|---|---|---|
| HR (bpm) | Sham | 146 (111–169) | 149 (117–180) | 137 (122–161) | 146 (127–159) | 0.78 |
| LPS | 133 (107–163) | 152 (128–164) | 147 (123–150) | 127 (113–142) | 0.12 | |
| MAP (mmHg) | Sham | 81 (64–99) | 85 (70–108) | 87 (73–100) | 68 (58–82) | 0.13 |
| LPS | 92 (79–103) | 59 (56–80)b | 57 (57–62)b | 63 (56–75) | 0.08 | |
| CO (L/min) | Sham | 2.2 (1.9-2.6) | 2.4 (2.2-2.9) | 2.5 (2.1-3.0) | 1.9 (1.6-2.6) | 0.10 |
| LPS | 2 (1.8-3.1) | 3 (2.8-4.7) | 3.1 (2.2-3.8) | 2.8 (2.2-3.4) | 0.18 | |
| MPAP (mmHg) | Sham | 11 (10–13) | 12 (10–13) | 11 (10–112) | 11 (8–11) | 0.15 |
| LPS | 13 (13–15)b | 19 (14–22)b | 18 (16–26)b | 18 (16–29)b | 0.07 | |
| PAOP (mmHg) | Sham | 5 (4–6) | 4.5 (4–5) | 3.5 (3–6) | 4 (3–5) | 0.80 |
| LPS | 8 (5–9) | 8 (6–9) | 8 (7–8)b | 8 (7–8)b | 0.56 | |
| Minute ventilation (L/min) | Sham | 5.7 (5.2-6.4) | 5.7 (4.8-6.4) | 5.8 (4.8-6.6) | 5.0 (4.4-6) | 0.17 |
| LPS | 5.9 (5.6-6.4) | 6.2 (5.5-6.9) | 6.3 (5.5-7.6) | 6.5 (5.8-7.7)b | 0.35 | |
| Plateau pressure (mmHg) | Sham | 21 (18–22) | 21 (20–23) | 23 (19–25) | 22 (21–23) | 0.40 |
| LPS | 19 (18–22) | 24 (20–27) | 24 (21–29) | 25 (22–28) | 0.02 | |
| RR (bpm) | Sham | 16 (15–17) | 16 (14–17) | 16 (14–17) | 16 (14–16) | 0.80 |
| LPS | 17 (16–19) | 19 (16–19) | 19 (16–22) | 19 (16–22) | 0.21 | |
| DO2 (ml O2/min) | Sham | 260 (137–343) | 290 (255–419) | 270 (266–373) | 214 (195–334) | 0.06 |
| LPS | 224 (203–337) | 277 (235–364) | 221 (167–358) | 203 (158–290) | 0.18 | |
| VO2 (ml O2/min) | Sham | 97 (58–132) | 99 (83–106) | 94 (74–111) | 85 (62–96) | 0.06 |
| LPS | 67 (54–86) | 64 (56–75) | 63 (53–76) | 67 (59–85) | 0.80 | |
| O2ER (%) | Sham | 0.33 (0.25-0.37) | 0.29 (0.25-0.4) | 0.29 (0.25-0.41) | 0.31 (0.26-0.47) | 0.56 |
| LPS | 0.28 (0.24-0.31) | 0.24 (0.17-0.30) | 0.30 (0.18-0.36) | 0.35 (0.25-0.42) | 0.17 | |
| SvO2 (%) | Sham | 69 (65–74) | 67 (63–74) | 70 (60–75) | 68 (55–75) | 0.32 |
| LPS | 77 (70–78) | 76 (67–84) | 68 (61–84) | 65 (54–77) | 0.09 |
CO, cardiac output; DO2, oxygen delivery; HR, heart rate; LPS, lipopolysaccharide; MAP, mean arterial pressure; MPAP, mean pulmonary arterial pressure; O2ER, oxygen extraction rate; PAOP, pulmonary artery occlusion pressure; RR, respiratory rate; SvO2, mixed venous oxygen saturation; VO2, oxygen consumption. Values are presented as median (interquartile range). P <0.05 considered as significant. aSignificant changes over time within groups. Comparison made with Friedman’s test and Bonferroni’s post-hoc correction. bSignificant difference between groups at the same time point. Comparison made with Mann–Whitney U test.