Table 2.
TGFB1 C-509T and TGFBR2 G-875A polymorphisms and lung adenocarcinoma risk
| Polymorphism | Cases | Controls | OR adg | 95% CI | P |
|---|---|---|---|---|---|
| TGF-β1 C-509T | |||||
| CC | 78(28.7) | 79(25.2) | 1.0 | ||
| CT | 138(50.7) | 162(51.8) | 0.847 | 0.574-1.249 | 0.402 |
| TT | 56(20.6) | 72(23.0) | 0.768 | 0.480-1.228 | 0.270 |
| CT/TT | 194(71.3) | 234(74.8) | 0.822 | 0.569-1.188 | 0.298 |
| C | 294(54.0) | 320(51.1) | 1.0 | ||
| T | 250(46.0) | 306(48.9) | 0.878 | 0.697-1.106 | 0.270 |
| TGFBR2 G-875A | |||||
| GG | 182(66.9) | 202(64.5) | 1.0 | ||
| GA | 80(29.4) | 102(32.6) | 0.865 | 0.605-1.237 | 0.427 |
| AA | 10(3.7) | 9(2.9) | 1.223 | 0.486-3.078 | 0.669 |
| GA/AA | 90(33.1) | 111(35.5) | 0.895 | 0.634-1.263 | 0.528 |
| G | 444(81.6) | 506(80.8) | 1.0 | ||
| A | 100(18.4) | 120(19.2) | 0.946 | 0.704-1.271 | 0.711 |
| Combined analysis | |||||
| 0 Variant locus | 54(19.9) | 42(13.4) | 1.0 | ||
| 1Variant locus | 152(55.9) | 197(62.9) | 0.591 | 0.374-0.935 | 0.025 |
| 2 Variant locus | 66(24.3) | 74(23.6) | 0.675 | 0.399-1.141 | 0.142 |
Abbreviation: OR adg age-adjusted odds ratio, CI confidence interval.