Table 3.
TGF-β1 C-509T and TGFBR2 G-875A polymorphisms and lung adenocarcinoma risk, stratified by cooking oil fume exposure
| Polymorphism | Exposure to cooking oil fume | Non exposure to cooking oil fume | P interaction | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | OR adg | 95% CI | P | Cases | Controls | OR adg | 95% CI | P | ||
| TGF-β1 C-509T | 0.046 | ||||||||||
| CC | 31 | 20 | 1.0 | 47 | 59 | 1.0 | |||||
| CT | 54 | 40 | 0.887 | 0.441-1.784 | 0.737 | 84 | 122 | 0.841 | 0.523-1.354 | 0.477 | |
| TT | 13 | 23 | 0.362 | 0.149-0.878 | 0.025 | 43 | 49 | 1.065 | 0.606-1.870 | 0.827 | |
| CT/TT | 67 | 63 | 0.693 | 0.358-1.342 | 0.277 | 127 | 171 | 0.906 | 0.578-1.420 | 0.666 | |
| TGFBR2 G-875A | 0.005 | ||||||||||
| GG | 59 | 60 | 1.0 | 123 | 142 | 1.0 | |||||
| GA | 34 | 23 | 1.451 | 0.761-2.766 | 0.258 | 46 | 79 | 0.674 | 0.435-1.047 | 0.079 | |
| AA | 5 | 0 | 5 | 9 | 0.629 | 0.205-1.929 | 0.417 | ||||
| GA/AA | 39 | 23 | 1.664 | 0.883-3.136 | 0.115 | 51 | 88 | 0.670 | 0.439-1.022 | 0.063 | |
Abbreviation: OR adg age-adjusted odds ratio, CI confidence interval.