Table 3.
Association between mineral metabolism measurements and the presence and severity of CAVD
| Variable | Univariate |
Multivariate |
||
| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Presence of CAVD | ||||
| Total cholesterol | 1.355 (1.083–1.695) | 0.008 | 0.873 (0.318–2.396) | 0.793 |
| LDL-cholesterol | 1.320 (1.011–1.724) | 0.041 | 1.014 (0.297–3.459) | 0.982 |
| Serum calcium | 14.845 (7.298–30.197) | <0.001 | 10.018 (3.364–29.835) | <0.001 |
| Serum phosphate | 9.840 (5.721–16.922) | <0.001 | 3.945 (1.955–7.959) | <0.001 |
| AKP | 1.058 (1.041–1.076) | <0.001 | 1.037 (1.013–1.062) | 0.003 |
| 25-OHD | 0.943 (0.930–0.957) | <0.001 | 0.950 (0.932–0.969) | <0.001 |
| iPTH | 1.077 (1.058–1.097) | <0.001 | 1.068 (1.041–1.097) | <0.001 |
| Severity of CAVD | ||||
| Serum calcium | 5.662 (2.829–11.331) | <0.001 | 6.984 (2.736–17.825) | <0.001 |
| Serum phosphate | 3.275 (2.097–5.116) | <0.001 | 3.665 (1.985–6.765) | <0.001 |
| AKP | 1.018 (1.008–1.029) | 0.001 | 1.016 (1.003–1.029) | 0.019 |
| 25-OHD | 0.975 (0.959–0.991) | 0.002 | 0.971 (0.951–0.992) | 0.006 |
| iPTH | 1.032 (1.020–1.044) | <0.001 | 1.037 (1.021–1.053) | <0.001 |
OR: odds ratio; CI: confidence interval; CAVD: calcific aortic valve disease; LDL: low density lipoprotein; AKP: alkaline phosphatase; 25-OHD: 25-hydroxyvitamin D; iPTH: intact parathyroid hormone