Table 2.

Immunophenotypic and Molecular Characteristics of Small Lymphocyte–Like Plasma Cell Myeloma

	Flow Cytometric Plasma Cell Immunophenotype									Microarray Signal*
Case No.	CD45	CD19	CD20	CD56	CD38	CD138	CD117	Cytogenetics	Group	MS4A1	PAX5	VPREB3
1	−	−	−	ND	+	+	−	46,XY[cp20]	CD-2	466.30	332.70	109.70
2	−	−	+	−	+	+	−	46,XY,t(6;10)(p12;p13)[20]	CD-2	15,335.70	266.00	91.60
3	−	ND	−	−	+	+	+	46,XX[20]	CD-2	3,842.00	559.40	15.10
4	−	ND	−	−	+	+	−	46,XX[191/45,XX,−20[11]	MF†	968.20	204.20	100.70
5	−	ND	−	+	+	+	+	46,XY[20]	CD-2	2,267.00	315.50	113.70
6	−	ND	−	−	+	+	+	46,XX[20], t(11;14)(q13;q32)  (positive by FISH)	CD-2	372.10	256.70	39.00
7		ND			+	+		46,XY,t(11;14)(q12~13.1;q32),  del(13)(q14q22),?del(17)(p12)  [cp2]/46,XY[18]	CD-1	35.50	138.10	82.40
8	−	ND	+	−	+	+	+	45,XY,t(11;14)(q12~13.1;q32),  −13[11/46,XY[cp19]	CD-2	17,436.40	188.40	40.30
9	−	ND	+	−	+	+	−	46,XY,der(14)t(11;14)(q13;q32)  [41/46,XY[81]	CD-2	7,569.80	199.00	56.90
10	−	ND	+	−	+	+	−	46,XY[20]	CD-2	5,697.40	181.30	29.60
11	−	ND	+	−	+	+	−	46,XX[20],t(11;14)(q13;q32)  (positive by FISH)	CD-2	6,569.70	104.10	89.40
12	ND	ND	ND	ND	ND	ND	ND	46,XY[20]	MY‡	9,123.90	360.60	67.50

FISH, fluorescence in situ hybridization; MY, a “myeloid signature” characteristic of myeloid lineage cells; ND, not done.

^*The minimum, mean, median, and maximum signals in the CD-2 subgroup for all 351 cases for MS4A1 expression were 254.00, 7,712.94, 6,659.70, and 24,309.50, respectively; for PAX5 expression, 28.20, 224.33, 190.90, and 571.70, respectively; and for VPREB3 expression, 82.30, 7,379.15, 4,252.70, and 38,039.50, respectively.

^†MAFB (MAFB proto-oncogene) spike; high CCND2 (24,454).

^‡High CCND2 (14,790).