Table 2.

α-Cyano Ketones, Amides, and Esters as Nucleophiles in Phosphepine-Catalyzed Enantioselective [4+1] Annulations^a

entry			ee (%)	yield (%)b
1		R1 = H	94	85
2		OMe	94	97
3		CO2Me	94	83
4c			90	88
5			93	90
6			93	96
7	t-Bu		94	75
8	NMe2		83	73
9	NPh2		91	93
10			86	73
11			88	86
12d	OMe		82	61

^aAll data are the average of two experiments.

^bYield of purified product.

^cReaction was run at 0 °C.

^dReaction was run with 20% (R)–3.