Table 3. Hiostopathological features of screening-detected thyroid cancers (N=158) by categories of thyroid radiation dosea.
| Radiation dose, mGy | Odds Ratio (95% Confidence Interval) | |||
|---|---|---|---|---|
| <200 | 200-949 | 950-17,472 | P-valueb | |
| Tumor size at pathology, mm: ≤10 vs. 11-47 | 1 | 0.90 (0.38-2.15) | 1.06 (0.41-2.72) | 0.77 |
| Presence of tumor capsule: No vs. Yes | 1 | 0.50 (0.19-1.28) | 0.70 (0.24-2.10) | 0.96 |
| Lymphatic invasion: Yes vs. No | 1 | 1.04 (0.44-2.43) | 2.65 (0.96-7.36) | 0.03 |
| Blood vessel invasion: Yes vs. No | 1 | 1.76 (0.43-7.20) | 1.53 (0.32-7.24) | 0.88 |
| Intrathyroidal infiltration: Yes vs. No | 1 | 1.23 (0.53-2.86) | 2.96 (1.09-8.03) | 0.02 |
| Thyroid capsule invasion: Yes vs. No | 1 | 1.63 (0.39-6.79) | 2.10 (0.46-9.50) | 0.43 |
| Extrathyroidal spread: Yes vs. No | 1 | 0.44 (0.06-3.56) | 0.35 (0.04-3.17) | 0.52 |
| Multifocalityc: Yes vs. No | 1 | 2.24 (0.64-7.79) | 4.86 (1.30-18.1) | 0.02 |
| TC with other nodular pathologyd: Yes vs. No | 1 | 1.28 (0.48-3.39) | 1.57 (0.56-4.41) | 0.44 |
| Histopathological variant of PTC: Solid and Diffuse Sclerosing vs. Other | 1 | 0.64 (0.23-1.75) | 2.75 (0.99-7.65) | <0.01 |
Abbreviations: mm, millimeters; mGy, milligray; PTC, papillary thyroid cancer; TC, thyroid cancer.
a
Logistic regression models adjusted for age at the time of surgery and sex.
b
P values from the test of linear trend.
c
TC cases with more than one carcinoma at pathology.
d
TC cases with one or more thyroid follicular adenoma, nodular goiter or adenomatous goiter.