Table 4. Distribution of activating KIR plus inhibitory KIR and their respective ligands in chronic Chagas disease and controls.
| Control | CCD | NC | CCC | ||
|---|---|---|---|---|---|
| KIR-HLA | N = 165 | N = 131 | N = 87 | N = 44 | |
| Ligand | n (%) | n (%) | n (%) | n (%) | |
| KIR-C1 | |||||
| 2DS2+/2DL2-/C1+ | 7 (4.2) a , b | 16 (12.2) a | 6 (6.9) c | 10 (22.7) b , c | |
| 2DS2-/2DL2+/C1+ | 6 (3.6) | 4 (3.1) | 1 (1.1) | 3 (6.8) | |
| 2DS2+/2DL3-/C1+ | 12 (7.3) | 9 (6.9) | 6 (6.9) | 3 (6.8) | |
| 2DS2-/2DL3+/C1+ | 51 (30.0) | 53 (40.5) | 34 (39.1) | 19 (43.2) | |
| 2DS2+/2DL2-/2DL3-/C1+ | 0 (0.0) | 2 (1.5) | 0 (0.0) | 2 (4.5) | |
| 2DS2-/2DL2-/2DL3+/C1+ | 45 (27.3) | 50 (38.2) | 33 (37.9) | 17 (48.6) | |
| 2DS2+/2DL2-/2DL3+/C1+ | 7 (4.2) d , f | 14 (10.7) d | 5 (5.7) e | 8 (18.2) e , f | |
| 2DS2-/2DL2+/2DL3+/C1+ | 5 (3.) | 3 (2.3) | 1(1.1) | 2 (4.5) | |
| 2DS2+/2DL2+/2DL3-/C1+ | 12 (7.3) | 7 (5.3) | 6 (6.9) | 1 (2.3) | |
| 2DS2+/2DL2+/2DL3+/C1+ | 54 (32.7) | 30 (22.9) | 23 (26.4) | 7 (15.9) | |
| KIR- C2 | |||||
| 2DS1+/2DL1-/C2+ | 3 (1.8) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| 2DS1-/2DL1+/C2+ | 70 (42.4) | 43 (32.8) | 26 (29.9) | 21 (47.7) | |
| 2DS1+/2DL1+/C2+ | 47 (28.5) | 36 (27.5) | 29 (33.3) | 7 (15.9) | |
| KIR- Bw4 | |||||
| 3DS1+/3DL1+/Bw4+ | 41 (24.8) | 35 (26.7) | 25 (28.7) | 10 (22.7) | |
| 3DS1+/3DL1-/Bw4+ | 7 (4.2) | 3 (2.3) | 2 (2.3) | 1 (2.3) | |
| 3DS1-/3DL1+/Bw4+ | 72 (43.6) | 60 (46.3) | 36 (41.4) | 24 (54.5) | |
| KIR-HLA- A3/11 | |||||
| 3DL2+/A3+/A11+ | 50 (30.3) g | 25 (19.1) g | 18 (20.7) | 7 (15.9) | |
| 3DL2+/A3-/A11+ | 17 (10.6) | 6 (4.6) | 5 (5.8) | 1 (2.3) | |
| 3DL2+/A3+/A11- | 33 (20.0) | 19 (14.5) | 13 (14.9) | 6 (13.6) | |
| 3DL2+/A3-/A11- | 118 (71.5) | 106 (80.9) | 69 (79.3) | 37 (84.1) |
CCD: chronic Chagas disease patients; NC: without heart involvement patients, CCC: chronic chagasic cardiopathy patients.
a P = 0.020; Pc = 0.040; OR = 2.14; 95% CI = 1.25–7.88 (CCD vs Controls)
b P = 0.0002; Pc = 0.0004; OR = 6.64; 95% CI = 2.30–18.60 (CCC vs Controls)
c P = 0.010; Pc = 0.020; OR = 3.97; 95% CI = 1.34–11.79 (CCC vs NC)
d P = 0.050; Pc = 0.100; OR = 1.06; 95% CI = 1.1–6.9 (CCD vs Controls)
e P = 0.040; Pc = 0.080; OR = 3.64; 95% CI = 1.12–11.91 (CCC vs NC)
f P = 0.004; Pc = 0.008; OR = 5.02; 95% CI = 1.71–14.73 (CCC vs Controls)
g P = 0.036; Pc = 0.144; OR = 0.54; 95% CI = 0.31–0.94 (CCD vs Controls)