Fig 6. Breast, circulatory and bone compartments.

Solution of the system of ODEs with and without treatment. From the top-left to the bottom-right, we show the solution of Eqs (3, 7) with ϕ from 1 to 4, Eqs (4, 8) and Eqs (5, 9). Continuous blue lines show the case without treatments, and dashed red lines shows the case with bisphosphonates administration. Dotted black lines show the case without TGF-β differences between cell phenotypes: $R_{\mathrm{\text{ec}}}^{\star }{(\varphi )}^{g(\varphi )}=R_{\mathrm{\text{ec}}}^{\star }{(1)}^{g(1)}$ for all ϕ. The time is in years.