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Domain structure and organization of COMP. N-terminal pentamerizing, EGF-like, type 3 repeat and C-terminal globular domain are indicated. ADAMTS-7, ADAMTS-12 and GEP bind to the EGF domain of COMP. Abbreviations: ADAMTS, a disintegrin and metalloproteinase with thrombospondin motifs; COMP, cartilage oligomeric matrix protein; EGF, epidermal growth factor; GEP, granulin-epithelin precursor.
