Table 1.
The known substrates and inhibitors of the ADAMTS family of enzymes.
| Enzyme (ADAMTS-) | Alternative name | Known substrate(s) | Known inhibitor(s) |
|---|---|---|---|
| 1 | METH-1 | Aggrecan, versican | NA |
| 2 | PCINP | Collagen I, II and III N-propeptides | Papilin, chordin-derived peptides |
| 3 | KIAA0366 | Procollagen II N-propeptide | NA |
| 4 | Aggrecanase-1 | Aggrecan, brevican, COMP, decorin, fibromodulin, versican | TIMP-3, TIMP-1, TIMP-2, α2M, C-terminal portion of fibronectin |
| 5 | Aggrecanase-2, ADAMTS-11 | Aggrecan | TIMP-3, α2M |
| 6 | NA | NA | NA |
| 7 | ADAMTS-7B | COMP, α2M | α2M, GEP |
| 8 | METH-2 | Aggrecan | NA |
| 9 | KIAA1312 | Aggrecan, versican | NA |
| 10 | NA | NA | NA |
| 12 | NA | Aggrecan, COMP, α2M | α2M, GEP |
| 13 | vWFCP | von Willebrand factor | Thrombin |
| 14 | NA | Procollagen I N-propeptide | NA |
| 15 | NA | Aggrecan | NA |
| 16 | NA | α2M | NA |
| 17 | NA | NA | NA |
| 18 | NA | NA | NA |
| 19 | NA | Aggrecan | NA |
| 20 | NA | Aggrecan | NA |
Abbreviations: α2M, α2-macroglobulin; ADAMTS, disintegrin and metalloproteinase with thrombospondin motifs; COMP, cartilage oligomeric matrix protein; GEP, granulin-epithelin precursor; NA, not applicable; TIMP, tissue inhibitor of metalloproteinases; vWFCP, von Willebrand factor cleaving protease.