Table 2.
Reduced Models of the Adjusted HRs and Medians for Total VMS Duration and Post-FMP Persistencea
| Total VMS Duration (n = 1368) |
Post-FM P Persistence (n = 772) |
|||||
|---|---|---|---|---|---|---|
| Predictor | HR (95% CI)b | Median Duration, y |
P Value | HR (95% CI)b | Median Persistence, y |
P Value |
| Age, yc | ||||||
| 42.0–44.9 | 1 [Reference] | >10.90 | <.005 | NAd | NA | .05 |
| 45.0–49.9 | 2.43 (1.30–4.51) | 9.34 | 1 [Reference]e | 6.76 | ||
| 50.0–54.9 | 2.71 (1.44–5.09) | 7.73 | 1.16 (0.84–1.60) | 5.72 | ||
| ≥55.0 | 3.60 (1.78–7.29) | 6.42 | 1.53 (1.05–2.24) | 4.48 | ||
| Menopausal transition stage | ||||||
| Premenopause | 1 [Reference] | >10.90 | <.001 | 1 [Reference] | >10.43 | .001 |
| Early perimenopause | 2.04 (1.35–3.11) | 10.06 | 1.48 (0.89–2.27) | 6.61 | ||
| Late perimenopause | 3.55 (2.26–5.60) | 6.12 | 2.16 (1.33–3.49) | 4.47 | ||
| Postmenopause | 3.74 (2.34–5.98) | 5.66 | 2.04 (1.27–3.28) | 4.59 | ||
| Race/ethnicity | ||||||
| Non-Hispanic white | 1 [Reference] | 9.01 | <.008 | 1 [Reference] | 5.43 | .048 |
| African American | 0.75 (0.58–0.96) | >10.90 | 0.79 (0.60–1.04) | 6.88 | ||
| Chinese | 1.80 (1.17–2.76) | 5.45 | 1.84 (1.14–2.95) | 3.05 | ||
| Hispanic | 1.97 (0.56–6.92) | 4.78 | 1.06 (0.19–5.84) | 4.92 | ||
| Japanese | 1.00 (0.66–1.51) | 9.34 | 0.91 (0.57–1.45) | 5.77 | ||
| Educational level ≥college | ||||||
| No | 1 [Reference] | 9.93 | .03 | 1 [Reference] | 6.54 | .003 |
| Yes | 1.25 (1.03–1.52) | 7.66 | 1.40 (1.13–1.74) | 4.54 | ||
| Symptom sensitivity at first annual follow-upf | ||||||
| Very low | 1 [Reference] | 7.36 | .05 | 1 [Reference] | 4.38 | .049 |
| Low | 0.77 (0.58–1.00) | 9.57 | 0.76 (0.56–1.04) | 5.48 | ||
| Moderate | 0.85 (0.64–1.13) | 8.22 | 0.78 (0.57–1.07) | 5.45 | ||
| High | 0.64 (0.46–0.89) | 10.81 | 0.58 (0.39–0.85) | 8.47 | ||
| Anxiety score ≥4c | ||||||
| No | NA | NA | NA | 1 [Reference] | 4.96 | .02 |
| Yes | NA | NA | 0.73 (0.56–0.95) | 7.40 | ||
| Perceived stressc,g | ||||||
| Never or almost never | 1 [Reference] | 8.00 | .02 | 1 [Reference] | 4.92 | .008 |
| At least sometimes | 0.75 (0.58–0.96) | 10.78 | 0.70 (0.54–0.91) | 8.13 | ||
| Depressive symptoms on the CES-D Scale ≥16c | ||||||
| No | 1 [Reference] | 7.73 | .005 | NA | NA | NA |
| Yes | 0.66 (0.50–0.88) | >10.90 | NA | NA | ||
Abbreviations: CES-D, Center for Epidemiologic Studies–Depression; FMP, final menstrual period; HR, hazard ratio; NA, not applicable; VMS, vasomotor symptoms.
Adjusted for all variables listed and for site. The total sample sizes are smaller than those in Table 1 because of missing data for some covariates.
Compared with the reference group, an HR exceeding 1.0 indicates shorter duration, an HR of less than 1.0 indicates longer duration, and an HR of 1.0 indicates no difference in duration.
At first VMS report for VMS duration and at first post-FMP report of frequent VMS for post-FMP persistence.
This variable was omitted in the backward elimination analysis.
Because the number of women in the age category of 42.0 to 44.9 years was very small for post-FMP persistence, the 2 lowest age categories were combined so that the reference category was up to age 49.9 years.
Very low is below the mean −1 SD (<6.9), low is between the mean and −1 SD (7.0–10.4), moderate is between the mean and 1 SD (10.5–13.8), and high is above the mean +1 SD (>13.8).
A score between 5 and 10 is never or almost never, and a score between 11 and 25 is at least sometimes.