Figure 3.

Variations of HEPs, k_f’ and CK flux based on the two-site exchange model in Figure 1b. a) Case (1): if k_f’ and k_r’ are static over time, buffering of the variations in ATP by the PCr pool is very small. b) Case (2): if both, k_f’ and k_r’ are equal to zero, no exchange between ATP and PCr occurs and ATP is not buffered by the PCr pool. c) Case (3): if k_f’ (PCr to ATP conversion) is variable over time, changes in ATP can be completely mediated to the PCr pool. d) Variation in k_f’ (PCr to ATP conversion) and CK flux (product of k_f’ and C_PCr) when variations in ATP are fully buffered (Case(3)). Three cardiac cycles are show at a heart rate of 60min⁻¹.