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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: NMR Biomed. 2015 Apr 23;28(6):694–705. doi: 10.1002/nbm.3302

Figure 8.

Figure 8

Variations of the forward (CK flux) and reverse reaction velocities vCK,f (a) and vCK,r (b) of the CK reaction and vsyn (c) of ATP synthesis from ADP and Pi. The four considered cases of 100%, 50%, 30% and 10% CK activity and three cardiac cycles at a heart rate of 60min−1 are shown. Both vCK,f and vCK,r are reduced with decreasing CK activity. Beside the temporal mean values, also the magnitude of cyclic variations of vCK,f are reduced (a). While cyclic changes in vsyn are small for 100% CK activity and only slightly increased for 50% and 30% CK activity, cyclic variations in vsyn are dramatically increased for 10% CK activity indicating a stronger challenge of the ATP synthesis system at very low CK activities.