Fig 2. cSiO₂ exposure accelerates development of proteinuria in NZBWF1 mice.

Proteinuria was monitored weekly until sacrifice 12 wk after the final cSiO₂ exposure when most mice exposed to 1.0 mg cSiO₂ were over threshold (≥ 300 mg/dl). Proteinuria was not detected in NZBWF1 mice dosed with 0.25 mg cSiO₂ or vehicle. C57Bl/6 mice exposed to cSiO₂ or vehicle did not develop detectable proteinuria over the course of the experiment.