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. 2015 May 15;10(5):e0125481. doi: 10.1371/journal.pone.0125481

Fig 10. cSiO2 exposure increases proinflammatory cytokines MCP-1 (A, D), TNF-α (B, E), and IL-6 I (C, F) in BALF and plasma of NZBWF1 mice.

Fig 10

Proinflammatory cytokine concentrations in BALF and plasma were determined by cytometric bead array. Data are group mean ± SEM (n = 5–8/gp) and were analyzed by one-way ANOVA on Ranks with Dunn’s method. Asterisk indicates a statistically significant difference in analyte between cSiO2 treatment and vehicle control (p < 0.05). cSiO2 dose correlated significantly (p < 0.05) with BALF MCP-1 (Spearman rank-order correlation coefficient = 0.90), BALF TNF-α (Spearman rank-order correlation coefficient = 0.89), and BALF IL-6 (Spearman rank-order correlation coefficient = 0.82). cSiO2 dose also correlated significantly (p < 0.05) with plasma TNF-α (Spearman rank-order correlation coefficient = 0.60), and IL-6 (Spearman rank-order correlation coefficient = 0.49). n.d. indicates not detected.