Table 5. Top 10 gene classifications of molecules in networks using IPA.
| Top functions | Molecules ‡ in Network | Score | Focus molecules |
|---|---|---|---|
| Infectious Disease, Antimicrobial Response, Inflammatory Response | ADAR, BPI, RIG-I, EIF2AK2, ENPP1, EPCAM, HERC5, IFI6, IFI27, Ifi47, MDA-5, IFIT1, ISG-54, IFIT3, IFIT5, IRF3, IRF9, IRG, ISG15, MX1, OAS1, OAS2, PASK, RSAD2, STAT2, TNFSF10, UBA7 | 40 | 27 |
| Tissue Morphology, Cell-To-Cell Signaling and Interaction | AGRN, C1QB, C1QC, DCN, ELF5, ETS2, EVI2A, FMOD, GBP7, GDF11, GPC1, KLRC1, KLRD1, LAG3, MHC Class I (complex), MRPL44 (includes EG:301552), MYL4 , NAIP, PPAP2C, SGPP1, SIGLEC1, ST14, TFEC, XAF1 | 37 | 24 |
| Connective Tissue Development and Function, Lipid Metabolism, Small Molecule Biochemistry | CDH13, CDH17, CDH20, CIDEC, CLEC1B, DECTIN-2, CTLA4, FCGR3A, ICOS, LY6E, MPPE1, PDE3B, PLIN1, PRKAR2B, SAA, SAMSN1, STMN2, THRSP, TRIM21, TULP2 | 29 | 20 |
| Gene Expression, Gastrointestinal Disease, Inflammatory Disease | BATF2, C1QB, CDH13, CLEC4A, CLEC4E, CLEC4F, CMPK2, DDIT4L, DTX3L, FAM26F, HERC6, IFI6, IL22RA2, NAALADL1, PARP9, SAMD9, SHISA2, SLC22A16, TMC6 | 27 | 19 |
| Infectious Disease, Cell-To-Cell Signaling and Interaction, Cellular Movement | ALDH9A1, APOL3, BTN1A1, CCL20, CCL22, CLCA1, CXCL10, IDO1, Oas, PLB1 (includes EG:151056), RNASE1, RNASEL, TBK1, TNFRSF4, TRIM25, UBE2L6, USP18, DAI | 25 | 18 |
| Small Molecule Biochemistry, Inflammatory Response, Drug Metabolism | ADIPOQ, BST2, C1RL, CD40LG, FABP4, GSTM1, Gstt3, HP, HPGDS, IL1A, LYZ, PLA2G2A, PLSCR1, SAA1, SERPINE2, SPINK5, UBD, VANGL2 | 25 | 18 |
| Tissue Development, Connective Tissue Development and Function, Skeletal and Muscular System Development and Function | ACVR1C, ADCY6, CACNA1H, CD1A, CTGF, CYP24A1, ECM1 (includes EG:100332249), EPHA7, FCER1G, HOMER2, IGFBP5, KLF5, LY9, P2RX7, PAPSS2, SH3GL2, SMPD3, SPP1 (includes EG:20750), TLR10, TNXB | 24 | 20 |
| Cell-mediated Immune Response, Cellular Movement, Hematological System Development and Function | ACP6, ADRA1D, ARRDC4, C3AR1, C5orf13, CALCRL, CCR4, CCR8, GNG7, GPR15, GPR126, GPR143 , HRH4, P2RY13, RGS1, WARS | 20 | 16 |
| Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry | ACRBP, CERS6, CIDEC, CLCA1, D4S234E, DDO, HUNK, KIRREL3, LMO3, PLIN4, PODXL2, POSTN, SCUBE1, SLC41A2, TDRD7 | 19 | 15 |
| Cell-To-Cell Signaling and Interaction, Nervous System Development and Function, Behaviour | ANXA3, ASL, BCO2, DENND2A, FADS3, FMOD, GLS2, HUNK, IGSF6, KLHDC8B, LYPD1, LYSMD2, RTP4, STS, TRIB2 | 19 | 15 |
‡Genes more highly expressed in the Suffolk breed are in bold while gene that are more highly expressed s in the Texel breed are in normal typeface.