Table 2. Macular ganglion cell inner plexiform layer thickness, macular ganglion cell complex thickness and circumpapillary retinal nerve fiber layer thickness measurements by swept source optical coherence tomography and spectral domain optic coherence tomography.
| SS-OCT | SD-OCT | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| mGCIPL (μm)mean ± SD | Control n = 41 | Glaucoma n = 106 | P value | Early Glaucoma n = 68 | P value * | Control n = 41 | Glaucoma n = 106 | P value | Early Glaucoma n = 68 | P value * |
| AVG | 70.5 ± 5.5 | 60.4 ± 7.2 | < 0.001 | 62.3 ± 6.5 | < 0.001 | 82.1 ± 6.6 | 67.9 ± 10.0 | < 0.001 | 71.3 ± 8.9 | < 0.001 |
| SUP | 68.7 ± 6.1 | 58.8 ± 8.2 | < 0.001 | 60.2 ± 7.5 | < 0.001 | 82.8 ± 7.3 | 69.4 ± 11.6 | < 0.001 | 72.4 ± 10.6 | < 0.001 |
| SN | 73.2 ± 6.0 | 62.6 ± 9.9 | < 0.001 | 65.1 ± 7.9 | < 0.001 | 84.1 ± 7.1 | 72.0 ± 11.8 | < 0.001 | 74.9 ± 9.7 | < 0.001 |
| ST | 71.7 ± 5.5 | 63.7 ± 6.6 | < 0.001 | 65.1 ± 6.3 | < 0.001 | 80.6 ± 6.2 | 67.5 ± 10.5 | < 0.001 | 70.3 ± 9.7 | < 0.001 |
| INF | 65.8 ± 6.1 | 55.1 ± 7.9 | < 0.001 | 56.9 ± 7.5 | < 0.001 | 80.7 ± 7.5 | 64.7 ± 11.4 | < 0.001 | 68.6 ± 10.6 | < 0.001 |
| IN | 71.1 ± 6.0 | 59.8 ± 9.3 | < 0.001 | 62.8 ± 7.9 | < 0.001 | 82.0 ± 6.9 | 68.9 ± 12.2 | < 0.001 | 72.8 ± 10.5 | < 0.001 |
| IT | 72.7 ± 5.3 | 62.3 ± 6.8 | < 0.001 | 63.8 ± 6.6 | < 0.001 | 82.3 ± 6.6 | 64.8 ± 10.5 | < 0.001 | 68.4 ± 9.7 | < 0.001 |
| Minimum | N/A | N/A | N/A | N/A | N/A | 79.5 ± 6.3 | 58.9 ± 11.4 | < 0.001 | 64.2 ± 11.3 | < 0.001 |
| mGCC (μm)mean ± SD | Control | Glaucoma | P value | EG | P value * | Control | Glaucoma | P value | EG | P value * |
| AVG | 107.9 ± 8.1 | 88.3 ± 12.8 | < 0.001 | 93.1 ± 10.7 | < 0.001 | 114.6 ± 7.2 | 94.8 ± 14.7 | < 0.001 | 100.2 ± 12.4 | < 0.001 |
| SUP | 108.4 ± 9.0 | 90.1 ± 15.1 | < 0.001 | 94.6 ± 12.3 | < 0.001 | 118.4 ± 8.4 | 99.7 ± 17.6 | < 0.001 | 104.6 ± 14.6 | < 0.001 |
| SN | 118.3 ± 8.0 | 101.8 ± 16.5 | < 0.001 | 105.9 ± 13.8 | < 0.001 | 121.5 ± 7.7 | 105.2 ± 17.7 | < 0.001 | 109.4 ± 14.0 | < 0.001 |
| ST | 96.6 ± 6.9 | 80.3 ± 12.6 | < 0.001 | 84.2 ± 10.3 | < 0.001 | 104.0 ± 6.3 | 87.2 ± 14.3 | < 0.001 | 91.5 ± 12.1 | < 0.001 |
| INF | 106.9 ± 10.0 | 83.7 ± 14.2 | < 0.001 | 89.3 ± 12.5 | < 0.001 | 117.1 ± 8.4 | 92.1 ± 18.3 | < 0.001 | 99.2 ± 16.3 | < 0.001 |
| IN | 117.8 ± 10.2 | 96.0 ± 16.4 | < 0.001 | 102.1 ± 14.2 | < 0.001 | 120.7 ± 7.8 | 100.5 ± 17.9 | < 0.001 | 107.2 ± 14.7 | < 0.001 |
| IT | 99.4 ± 7.8 | 77.8 ± 12.7 | < 0.001 | 82.5 ± 11.4 | < 0.001 | 106.7 ± 6.5 | 83.7 ± 15.2 | < 0.001 | 89.1 ± 13.8 | < 0.001 |
| MIN | N/A | N/A | N/A | N/A | N/A | 94.5 ± 7.0 | 70.2 ± 14.6 | < 0.001 | 75.5 ± 14.2 | < 0.001 |
| cpRNFL (μm)mean ± SD | Control | Glaucoma | P value | EG | P value * | Control | Glaucoma | P value | EG | P value * |
| Average | 102.4 ± 15.6 | 71.1 ± 18.2 | < 0.001 | 79.3 ± 14.3 | < 0.001 | 95.3 ± 8.6 | 72.4 ± 12.1 | < 0.001 | 76.5 ± 11.0 | < 0.001 |
| SUP | 125.6 ± 20.4 | 84.4 ± 23.9 | < 0.001 | 93.0 ± 20.8 | < 0.001 | 121.8 ± 13.5 | 86.9 ± 18.1 | < 0.001 | 92.3 ± 16.2 | < 0.001 |
| INF | 131.6 ± 23.5 | 82.5 ± 29.0 | < 0.001 | 95.5 ± 25.0 | < 0.001 | 125.5 ± 16.5 | 84.5 ± 22.3 | < 0.001 | 92.6 ± 21.2 | < 0.001 |
| NAS | 75.2 ± 15.2 | 58.3 ± 20.4 | < 0.001 | 63.9 ± 15.3 | < 0.001 | 69.2 ± 8.1 | 66.0 ± 10.4 | < 0.001 | 66.6 ± 11.2 | < 0.001 |
| TEMP | 77.3 ± 18.0 | 59.1 ± 16.2 | < 0.001 | 64.6 ± 12.7 | < 0.001 | 64.9 ± 12.5 | 52.4 ± 11.2 | < 0.001 | 54.8 ± 10.1 | < 0.001 |
Abbreviations: SS-OCT = swept source optic coherence tomography; SD-OCT = spectral domain optic coherence tomography; mGCIPL = macular ganglion cell inner plexiform layer; mGCC = macular ganglion cell complex; cpRNFL = circumpapillary retinal nerve fiber layer; EG = early glaucoma; SD = standard deviation; AVG = average; SUP = superior; INF = inferior; NAS = nasal; TEMP = temporal; SN = superonasal; IN = inferonasal; ST = superotemporal; IT = inferotemporal; MIN = minimum.
* Healthy vs. EG.