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. 2015 May 15;10(5):e0126726. doi: 10.1371/journal.pone.0126726

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© 2015 Zhao et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 5 — HGC27 tumor xenografts were induced in balb/c nude mice by s.c. injection of 5×10⁶cells. Three daily injections of Ad-TERTp-E1A-1504, Ad-TERTp-E1A-NC(both at 1×107pfu) or PBS were given intratumorally when the tumor xenogaft reached a diameter of >0.5cm. A: Representive xenografts when they were first treated with virus or PBS. The volume of them was similar. B-C: Representive xenografts euthanized. The volume of xenograft treated with Ad-TERTp-E1A-1504 was smaller than that with Ad-TERTp-E1A-NC and PBS in order. Growth rate was represented with mean±SE(n = 3). D: Western blot analysis of the expressions of E1A and EphA3 in xenograft tumor tissue treated with Ad-TERTp-E1A-1504, Ad-TERTp-E1A-NC and PBS.