Fig 1. Geographical distribution of plants producing pollen containing clinically relevant allergenic pectate lyases.

Light colored zones represent areas with low to medium distribution, dark colored zone areas with high distribution of the respective species. Ambrosia artemisiifolia (ragweed) is presented in blue, Artemisia vulgaris (mugwort) in violet, Cupressus arizonica / Cupressus sempervirens (cypress) in red, Juniperus ashei (Mountain cedar) in orange, and Cryptomeria japonica (Japanese cedar) in yellow. The 4 clinical centers of the study are depict as cross lines (www.gbif.org; www.pollenlibrary.com; eol.org) [3, 4].