Skip to main content
. Author manuscript; available in PMC: 2015 May 15.
Published in final edited form as: Curr Opin Neurobiol. 2014 Mar 30;27:75–81. doi: 10.1016/j.conb.2014.03.005

Figure 1.

Figure 1

Molecular mechanisms that govern neurogenic and gliogenic fates in neural stem cells. (a) During the neurogenic state, Ngn1 binds and sequesters the p300/CBP complex to prevent interactions with the gliogenic binding partner STAT3. Concomitant DNMT1 expression leads to methylation and subsequent repression of glial gene transcription. (b) Later in embryogenesis, proglial signals like BMPs, Notch, and CT-1 lead to the activation of the STAT3:p300/CBP complex. NFIA-mediated repression of DNMT1 helps to eliminate methylation at the GFAP promoter and results in a relaxed DNA confirmation where STAT3:p300/CBP can bind and initiate gliogenic gene transcription.