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. Author manuscript; available in PMC: 2015 May 15.
Published in final edited form as: Physiol Behav. 2012 Feb 2;106(2):164–170. doi: 10.1016/j.physbeh.2012.01.019

Figure 2.

Figure 2

Mean (± SEM) of total positive hedonic and negative affective responses in sham depleted and furosemide-sodium depleted rats in naltrexone/vehicle treated rats given intraoral (I–O) infusions of 0.3 M saline. Rats were either sham or sodium depleted and then given 0, 0.5, or 1 mg/kg i.p. of systemic naltrexone. (A) Naltrexone significantly attenuated positive hedonic responses in furosemide depleted rats as compared to vehicle treated sodium depleted rats. Positive hedonic responses in sham depleted rats were not affected by systemic naltrexone treatments. (B) Total number of negative affective behaviors was significantly increased in furosemide depleted rats given the highest dose (1 mg/kg) of naltrexone. Negative affective responses in sham depleted rats were not affected by systemic naltrexone treatment. *p<0.05 in vehicle (0 mg/kg) vs. naltrexone (0.5 mg/kg or 1 mg/kg) treatment groups