Table 1. General and Clinical Cohort Details.

Sex, n (%)
Male	43 (51.8)
Female	40 (48.2)
Age, years a	40.5±18 (5–79)
Genotype,	N370S/N370S	N370S/L444P	N370S/Others
n (%)	14 (16.8)	48 (57.9)	21 (25.3)
Spleen Status,	Non Splenectomized	Splenectomized
n (%)	62 (74.7)	21 (25.3)
Clinical history bone impairment,	Bone pain	Avascular necrosis/infarcts	Orthopaedic procedures
n (%)	35 (41.2)	33 (38.8)	12 (14.5)
BMI,	Normal	Underweight	Overweight	Obese
n (%) b	52 (71.2)	5 (6.8)	12 (16.4)	4 (5.5)
DXA, n (%)	29 (37.6)
BMD,	Normal	Osteopenia	Osteoporosis
n (%) c	14 (48.3)	10 (34.5)	5 (17.2)
US, n (%)	48 (62.4)
BMD,	Normal	Osteopenia	Osteoporosis
n (%) c	29 (60.4)	15 (31.3)	4 (8.3)
BUA(n),	Normal(25)	Osteopenia (15)	Osteoporosis(4)
db/Mhz a	82.36±14.07	55.43±11.43	38.37±8.6
S-MRI,	Low-Normal	Mild	Severe
n (%) d	57 (68.7)	13 (15.7)	13 (15.7)

a Values presented as mean±SD (range)

b Adjusted for age

c World Health Organization criteria classification Z-score, T-score adjusted for age

d S-MRI score classification: Low-Normal (0–5), Mild (6–10), Severe (>10).