Table 5. Regression analysis of diagnostic intervals by NICE status in 15 cancers.
| Cancer site | NICE status | n (%) | Diagnostic interval | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Median | Interquartile range | 90th centile | Mean difference (95% CI) | P value* | ||||
| Crude | Adjusted* | |||||||||
| Bladder | NICE | 1299 (85.5) | 109.5 | 99.0 | 71 | 37 to 155 | 284 | 62.9 | 62.9 (48.7 to 77.2) | <0.001 |
| non-NICE | 220 (14.5) | 175.0 | 105.9 | 172 | 87 to 268 | 327 | ||||
| Breast | NICE | 1316 (81.2) | 41.8 | 59.7 | 22 | 14 to 42 | 83 | 114.9 | 115.1 (105.9 to 124.3) | <0.001 |
| non-NICE | 304 (18.8) | 156.7 | 116.7 | 138 | 54 to 263 | 337 | ||||
| Cervical | NICE | 68 (45.3) | 66.6 | 63.2 | 43 | 27 to 90 | 179 | 57.4 | 60.3 (31.6 to 89.0) | <0.001 |
| non-NICE | 82 (54.7) | 124.0 | 99.8 | 90 | 49 to 192 | 273 | ||||
| Colorectal | NICE | 2508 (57.5) | 109.4 | 98.2 | 69 | 35 to 163 | 279 | 25.7 | 25.8 (19.6 to 31.9) | <0.001 |
| non-NICE | 1855 (42.5) | 135.1 | 108.2 | 100 | 43 to 218 | 310 | ||||
| Gastric | NICE | 1002 (89.6) | 122.4 | 106.9 | 80 | 35 to 195 | 309 | 25.0 | 24.1 (3.4 to 44.8) | 0.02 |
| non-NICE | 116 (10.4) | 147.3 | 113.5 | 117 | 48 to 244 | 329 | ||||
| Head and Neck | NICE | 282 (86.0) | 117.8 | 91.9 | 84 | 50 to 167 | 272 | 25.5 | 22.6 (-6.8 to 52.0) | 0.13 |
| non-NICE | 46 (14.0) | 143.3 | 106.8 | 101 | 55 to 218 | 312 | ||||
| Kidney | NICE | 272 (54.0) | 106.9 | 94.0 | 76 | 39 to 145 | 281 | 26.2 | 22.1 (4.5 to 39.7) | 0.01 |
| non-NICE | 231 (46.0) | 133.2 | 104.7 | 104 | 44 to 211 | 296 | ||||
| Leukaemia | NICE | 370 (96.6) | 134.4 | 114.3 | 103 | 28 to 231 | 312 | -26.4 | -39.5 (-102.2 to 23.1) | 0.21 |
| non-NICE | 13 (3.4) | 108.0 | 103.8 | 57 | 28 to 166 | 262 | ||||
| Lung | NICE | 3816 (89.7) | 146.2 | 113.8 | 112 | 44 to 248 | 327 | 11.3 | 8.8 (-2.4 to 20.0) | 0.12 |
| non-NICE | 437 (10.3) | 157.5 | 110.5 | 139 | 60 to 257 | 323 | ||||
| Lymphoma | NICE | 652 (95.2) | 131.1 | 102.9 | 100 | 46 to 210 | 295 | -23.0 | -22.8 (-58.4 to 14.0) | 0.23 |
| non-NICE | 33 (4.8) | 108.1 | 111.0 | 44 | 24 to 157 | 310 | ||||
| Myeloma | NICE | 497 (99.4) | 162.2 | 113.9 | 149 | 54 to 263 | 334 | -68.8 | -65.8 (-195.8 to 64.2) | 0.32 |
| non-NICE | 3 (0.6) | 93.3 | 130.9 | 28 | 8 to 244 | 244 | ||||
| Oesophagus | NICE | 1314 (94.6) | 121.9 | 106.5 | 79 | 34 to 200 | 300 | 67.2 | 67.0 (42.1 to 92.0) | <0.001 |
| non-NICE | 75 (5.4) | 189.1 | 117.0 | 169 | 89 to 306 | 352 | ||||
| Pancreatic | NICE | 859 (90.8) | 92.3 | 91.4 | 56 | 25 to 131 | 242 | 67.2 | 48.6 (28.1 to 69.1) | <0.001 |
| non-NICE | 87 (9.2) | 138.6 | 104.0 | 115 | 43 to 211 | 293 | ||||
| Testicular | NICE | 68 (65.4) | 41.5 | 32.5 | 35 | 20 to 57 | 77 | 37.4 | 36.7 (17.0 to 56.4) | <0.001 |
| non-NICE | 36 (34.6) | 78.9 | 68.0 | 56 | 29 to 110 | 182 | ||||
| Endometrial | NICE | 571 (75.4) | 81.9 | 69.9 | 58 | 33 to 107 | 176 | 72.9 | 73.8 (60.3 to 87.3) | <0.001 |
| non-NICE | 186 (24.6) | 155.6 | 107.5 | 135 | 63 to 239 | 320 | ||||
| Pooled | NICE | 14894 (80.0) | 115.7 | 105.1 | 73 | 32 to 183 | 296 | 27.5 | 27.7 (23.9 to 31.5) | <0.001 |
| non-NICE | 3724 (20.0) | 143.3 | 109.5 | 113 | 48 to 233 | 318 | ||||
*Model adjusted for age and gender (where relevant).