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. Author manuscript; available in PMC: 2015 May 15.
Published in final edited form as: Circ Res. 2003 Oct 30;93(12):1225–1232. doi: 10.1161/01.RES.0000104087.29395.66

Figure 8.

Figure 8

Rates of superoxide production in the presence of 2-DOG between static and oscillatory flow (OF) conditions. A, BAECs were incubated with 10 mmol/L of 2-DOG for 12 hours before SOD inhibited ferric cytochrome c reduction assay. The presence of 2-DOG significantly reduced the rates of superoxide formation between the control and 2-DOG samples, OF, and OF+2-DOG samples. The negative rates of superoxide production were attributable to the use of SOD. B, LDL oxidation in response to OF. The presence of 2-DOG significantly attenuated the extent of LDL oxidation, suggesting the role of NADPH as an important cofactor for superoxide production and the subsequent LDL oxidation.