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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Endocr Relat Cancer. 2015 Feb 24;22(3):353–367. doi: 10.1530/ERC-15-0038

Figure 5.

Figure 5

Immunohistochemistry of pituitary adenomas from Xq26.3 microduplication cases. In case S1 (sporadic male) Panel A demonstrates strong GHRH-R staining (brown) in the pituitary adenoma using a C-terminal GHRH-R peptide (20× magnification). The tumor was a mixed GH and PRL adenoma and staining of consecutive slices demonstrated largely different cell populations that stained for GH (brown; Panel B) and PRL (brown; Panel C). SSTR immunohistochemistry was also performed on tumors from patients with the Xq26.3 microduplication. AIP staining (brown) shown in 3 pituitary tumors from X-LAG syndrome cases (Panels D–F)). In all 6 cases tested AIP staining was preserved at moderate to high levels and was predominantly cytoplasmic (20× magnification).