Table 3.
Historical cases of extreme gigantism in which growth began in early childhood.
| Name | Country | Sex | Year of birth | Birth weight (kg) | Normal family history | Age at onset of abnormal growth (yr) | Final height (cm) |
|---|---|---|---|---|---|---|---|
| Martin Van Buren Bates1 | United States | M | 1837 | Normal | Y | 6 | 222 |
| Anna Haining Swan1 | Canada | F | 1846 | 8.1 | Y | <4 | 227 |
| Ella Kate Ewing | United States | F | 1872 | 3.4 | Y | 7 | 225 |
| Fedor Andreevich Machnow | Russia | M | 1878 | N/A | Y | 5 | 239 |
| Edouard Beaupré* | Canada | M | 1881 | 4.1 | Y | 3 | 251 |
| Joh(a)n Aasen* | United States | M | 1890 | N/A | N | <8 | 218 |
| Albert Johan Kramer* | Netherlands | M | 1897 | 8.5 | Y | <7 | 238 |
| Robert Pershing Wadlow* | United States | M | 1918 | 4.1 | Y | <3 | 272 |
| Cecil Boling | United States | M | 1920 | Normal | Y | <7 | 235 |
| Rigardus Rijnhout* | Netherlands | M | 1922 | Normal | Y | >3 | 238 |
| Dolores Ann Pullard+ | United States | F | 1946 | Normal | Y | 4 | 227 |
| Sandra Elaine (Sandy) Allen* | United States | F | 1955 | 2.95 | Y | 3 | 232 |
| Zeng Jinlian | China | F | 1965 | Normal | Y | <1 | 249 |
| Yao Defen* | China | F | 1972 | 2.8 | Y | <3 | 234 |
1
Swan and Bates were married and had two pregnancies; one female child was stillborn (weighed 8.1 kg) and later a son who died in early infancy was 10.8Kg and 76 cm in length when born.
*
cases for which pituitary pathology was reliably diagnosed/reported.