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Representative Hyper-CEST profile of 1.8 pM CB[6] in pH 7.2 PBS at 300 K. Saturation frequencies of Dsnob-shaped pulses were positioned at 122.3 ppm (193.5 – 71.2 ppm) and 264.7 ppm (193.5 + 71.2 ppm), for on- and off-resonance. Pulse length, τpulse = 1.05 ms; field strength, B1,max = 279 μT.
