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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Endocr Relat Cancer. 2015 Mar 25;22(3):345–352. doi: 10.1530/ERC-15-0069

Figure 1.

Figure 1

(A–D) Gastric stromal sarcoma (Case No. 1). Luxuriant filopodal cell borders (marked as F). Numerous glycogen granules (arrow) and prominent nucleoli (B). Mitochondria show abnormal cristae structure (*) (and inset B). Moderately increased numbers of mitochondria (C – D), all showing abnormal morphology; no cristae (*). (E – F) Gastric stromal sarcoma (Case No 2, specimen 6) Fewer numbers of oval and spindle cells with heavily lobulated nuclei (E, arrow) intracytoplasmic filamentous aggregates, slender surface filopodia (F) and a few short intercellular attachments were present. Polygonal and spindle cells were packed with cystic-looking mitochondria (*) without cristae and with intra-mitochondrial membranous inclusions (H, *). (G–I) CTr Gastrointestinal Stromal Tumors (Case no 2, specimen 6). Oval and spindle cells are in close apposition. Slender filopodia (F) are evident with few short intercellular attachments. The cytoplasm contains strands of rough endoplasmic reticulum (RER), branching ER, intermediate filaments and increased numbers of mitochondria (*). Mitochondria exhibit variable sizes and structural abnormalities – some are small and round, others are thin and elongated with tubular cristae. Many mitochondria have partial to complete loss of cristae and exhibit amorphous amorphous material containing membranous whorls or cystic structures.