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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Hypertension. 2015 Apr 13;65(6):1331–1340. doi: 10.1161/HYPERTENSIONAHA.115.05315

Figure 7. Bloom of acetate and butyrate producing bacteria upon treatment of minocycline.

Figure 7

A. Expansion of several genera observed in the fecal samples from rats administrated by minocycline and angiotensin II. Miseq reads of bacterial 16S ribosomal DNA were analyzed and assigned to specific genera based on the sequence similarities to Silva non-redundant 16S reference database. The most accumulated genera of bacteria were identified by LEfSe as Akkermansia, Bacteroides, Enterorhabdus and Marvinbryantia. B. The relative proportions of acetate, butyrate and lactate producing bacteria in the gut microbiota in the rats either untreated or treated with Angiotensin II or Angiotensin II plus minocycline. Sequence reads were classified according to the primary end product of the assigned bacterial genera. Results were compared by one-way ANOVA and Newman-Keuls post-hoc test; *p<0.05, **p<0.01. Control n=6, Ang II n=6, Ang II+Mino n=7.