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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Adv Healthc Mater. 2015 Feb 26;4(7):1092–1103. doi: 10.1002/adhm.201400738

Figure 4. MHT treatment enhances accumulation and spatial distribution of nanoliposomes.

Figure 4

A) Intravital microscopy images obtained 1 h after MHT treatment showing nanoliposomes (red); the liposomal accumulation in treatment group was indistinguishable from control group where nanoparticles remained in circulation (green, vessels; B) while analyses at 5 h after treatment revealed significant nanoparticle accumulation (red) in tumor interstitial space compared to untreated group; C) further analyses showed increased nanoparticle spatial distribution with tumor receiving MHT treatment showing liposomal dispersion of 21 ± 2.5 µm away from the nearest tumor vessels versus 3.7 ± 1.9 µm for untreated tumors; D) MHT treatment showed 3-fold increase in accumulation of nanoparticles at 5h and no significant enhancement at 1 h after treatment.