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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Adv Healthc Mater. 2015 Feb 26;4(7):1092–1103. doi: 10.1002/adhm.201400738

Figure 5. MHT treatment improves Gem-dependent tumor growth inhibition and reduction in tumor weight.

Figure 5

A) Combinational tumor therapy using MHT and i.v. infusion of Gem Lip at 6 and 12 mg/kg over 7 weeks. Tumor receiving with Gem Lip + MHT (twice weekly) showed a 2-fold increase in tumor inhibition compared to chemotherapy alone with notable inhibition starting on day 12 and continuing through day 49. B) Growth curves shows combinational therapy using free Gem slightly reduced tumor size compared to Gem treatment alone whereas use of Gem Lip treatment significantly increased tumor inhibition and achieved 5-fold dose reduction. C) Representative images of excised tumors at day 49 showing smallest to tumor size for combination use of Gem Lip + MHT relative to mono-therapy treatment. D) Inhibition is confirmed by reduction in tumor weights on day 49 where significant reduction is observed with Gem Lip plus MHT group while no significant difference was seen between MHT only and untreated group. Seven animals were used per group. Statistical significance is denoted by ** p < 0.039, *** p < 0.0032, ** p < 0.043 for n =7 for group.