Table 3. Twenty genes that show the highest fold increases or decreases in transcript levels in human ccRCC compared to normal human kidney from TCGA.
| TCGA q-value | TCGA Fold Change | Gene | fold-change TRACK TG+/TG- | p-value | q-value |
|---|---|---|---|---|---|
| Increased in ccRCC | |||||
| 2.85E-02 | 140.62 | HP | 4.47 | 5.00E-05 | 2.77E-04 |
| 2.59E-10 | 81.87 | GUCA2B | 0.88 | 7.30E-03 | 2.41E-02 |
| 1.74E-122 | 54.30 | CA9 | 9.34 | 5.00E-05 | 2.77E-04 |
| 6.09E-28 | 51.35 | FABP7 | 0.82 | 1.47E-02 | 4.36E-02 |
| 1.21E-23 | 47.63 | MCHR1 | 0.69 | 2.35E-03 | 9.01E-03 |
| 3.19E-02 | 45.56 | HHATL | 0.88 | 8.02E-02 | 1.73E-01 |
| 3.06E-105 | 44.88 | NDUFA4L2 | 67.93 | 5.00E-05 | 2.77E-04 |
| 6.80E-48 | 44.07 | HSF4 | 1.78 | 5.00E-05 | 2.77E-04 |
| 1.82E-45 | 34.72 | KISS1R | 1.06 | 9.80E-01 | 9.88E-01 |
| 9.17E-61 | 34.31 | CYP2J2 | 0.93 | 8.85E-01 | 9.38E-01 |
| 2.65E-41 | 31.87 | PNCK | 1.71 | 8.10E-03 | 2.63E-02 |
| 2.15E-33 | 31.45 | APOC1 | 1.62 | 4.45E-02 | 1.08E-01 |
| 5.89E-17 | 29.99 | CD5L | 0.39 | 5.00E-05 | 2.77E-04 |
| 2.20E-110 | 29.31 | ANGPTL4 | 0.76 | 5.00E-05 | 2.77E-04 |
| 1.34E-94 | 28.73 | COL23A1 | 1.34 | 2.23E-02 | 6.19E-02 |
| 2.92E-06 | 24.59 | LBP | 1.73 | 5.00E-05 | 2.77E-04 |
| 1.39E-91 | 21.66 | ENPP3 | 0.99 | 9.10E-01 | 9.52E-01 |
| 7.13E-94 | 20.73 | C7orf68 | 2.82 | 5.00E-05 | 2.77E-04 |
| 2.51E-26 | 19.66 | KCNN1 | 0.78 | 1.07E-02 | 3.34E-02 |
| 5.94E-44 | 19.58 | NXPH4 | 10.02 | 5.00E-05 | 2.77E-04 |
| Decreased in ccRCC | |||||
| 9.67E-16 | 0.002 | AQP2 | 1.260 | 5.00E-05 | 2.77E-04 |
| 3.20E-14 | 0.002 | UMOD | 1.039 | 5.04E-01 | 6.76E-01 |
| 5.23E-16 | 0.003 | SLC12A1 | 1.021 | 9.79E-01 | 9.88E-01 |
| 5.73E-13 | 0.004 | TMEM207 | 0.888 | 2.22E-01 | 3.80E-01 |
| 3.09E-11 | 0.005 | FXYD4 | 1.055 | 4.58E-01 | 6.34E-01 |
| 6.23E-12 | 0.006 | CALB1 | 1.019 | 6.95E-01 | 8.21E-01 |
| 2.95E-12 | 0.008 | NPHS2 | 1.249 | 5.00E-05 | 2.77E-04 |
| 1.70E-18 | 0.009 | DUSP9 | 1.043 | 5.90E-01 | 7.47E-01 |
| 1.18E-11 | 0.009 | SOST | 1.091 | 4.90E-01 | 6.64E-01 |
| 1.07E-20 | 0.013 | KNG1 | 1.284 | 1.07E-01 | 2.18E-01 |
| 5.63E-21 | 0.013 | HS6ST2 | 1.724 | 5.00E-05 | 2.77E-04 |
| 5.46E-12 | 0.014 | DDN | 1.071 | 3.69E-01 | 5.48E-01 |
| 3.20E-17 | 0.014 | CLDN16 | 1.068 | 4.52E-01 | 6.29E-01 |
| 1.07E-24 | 0.015 | KCNJ1 | 1.066 | 8.46E-01 | 9.18E-01 |
| 1.07E-24 | 0.015 | KCNJ1 | 1.031 | 5.19E-01 | 6.89E-01 |
| 1.05E-13 | 0.015 | ESRRB | 0.884 | 4.01E-02 | 9.96E-02 |
| 6.04E-24 | 0.016 | KCNJ10 | 1.113 | 2.36E-02 | 6.49E-02 |
| 1.22E-09 | 0.016 | SLC22A8 | 0.549 | 5.00E-05 | 2.77E-04 |
| 4.49E-24 | 0.016 | TFAP2B | 1.055 | 3.23E-01 | 4.99E-01 |
| 3.08E-21 | 0.017 | RALYL | 1.488 | 2.81E-02 | 7.49E-02 |
The list of the top 20 genes that show elevated or decreased transcript levels in human ccRCC was retrieved from TCGA. The fold changes in mRNA levels in these genes in TRACK TG+ mice versus TG- kidneys are listed.