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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Mol Cancer Res. 2015 Feb 13;13(5):839–851. doi: 10.1158/1541-7786.MCR-15-0006-T

Figure 1. LncRNA expression segregates with ALL cytogenetic subtypes.

Figure 1

(A) Hierarchical clustering of differentially regulated protein-coding gene expression data (adjusted p-value after correction for multiple hypothesis testing, p-adj<0.01) in 20 B-ALL samples with three common translocations, namely, t(12; 21), TEL-AML1(n=6); t(1;19) E2A-PBX (n=7); and t(4;11) MLL-AF4 (n=7). Genes that are relatively upregulated appear in green, and those that are relatively downregulated appear in red. (B) Hierarchical clustering of lncRNAs that were differentially expressed (adj. p-value<0.01) showed distinct separation into three subsets of B-ALL, corresponding to the cytogenetic abnormalities. (C–F) Plots of normalized intensity ratios of BALR-1, BALR-2, BALR-6, and LINC00958 in individual cases of B-ALL, respectively.