Figure 3.

Symptoms of Lower Respiratory Illness during the First Year of Life Are Associated with Viruses Present during the Infection and Predict Chronic Wheeze at 5 Years of Age

(A and B) Kaplan-Meier survival curves for age (days) at (A) first febrile LRI and (B) first HRV-C wheezy LRI, stratified by chronic wheeze status at 5 years. p values shown were estimated using Cox proportional hazards models, adjusted for gender and maternal and paternal history of atopic disease. Shaded areas indicate 95% confidence intervals.

(C) Frequencies of fever and wheeze symptoms during LRI, in which HRV-C and/or RSV were detected. Total numbers are: HRV-C only, n = 79; HRV-C and RSV, n = 14; RSV only, n = 22.

(D) Cross-tabulation of individuals according to their experience of LRI during infancy; percentages in brackets indicate frequency of chronic wheeze at 5 years.